Lamberts S W, Reubi J C, Krenning E P
Department of Medicine, Erasmus University, Rotterdam, The Netherlands.
Endocrinol Metab Clin North Am. 1992 Sep;21(3):737-52.
Medical therapy of acromegaly with the somatostatin analog octreotide is very successful. Both clinical symptomatology and hormonal hypersecretion by the growth hormone-secreting pituitary adenomas are controlled, and peripheral IGF-I levels also return to near normal levels. Tumor shrinkage is observed in most patients. Somatostatin analogs can be used after noncurative surgery and for a limited period after radiotherapy, and octreotide pretreatment might improve the outcome of surgery.
使用生长抑素类似物奥曲肽对肢端肥大症进行药物治疗非常成功。生长激素分泌型垂体腺瘤引起的临床症状和激素分泌过多均得到控制，外周胰岛素样生长因子-I（IGF-I）水平也恢复到接近正常水平。大多数患者的肿瘤出现缩小。生长抑素类似物可在非根治性手术后使用，也可在放疗后的有限时间段内使用，奥曲肽预处理可能会改善手术效果。
