使用经颅多普勒和99mTc-HM-PAO单光子发射计算机断层扫描对单侧颈内动脉阻塞患者进行乙酰唑胺刺激试验。

Acetazolamide stimulation test in patients with unilateral internal carotid artery obstructions using transcranial Doppler and 99mTc-HM-PAO-Spect.

作者信息

Rosenkranz K, Hierholzer J, Langer R, Hepp W, Palenker J, Felix R

机构信息

Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Germany.

出版信息

Neurol Res. 1992;14(2 Suppl):135-8. doi: 10.1080/01616412.1992.11740033.

DOI:10.1080/01616412.1992.11740033

PMID:1355870

Abstract

Fifteen patients with symptoms of cerebral ischaemia and angiographically confirmed unilateral stenoses or occlusions of the extracranial internal carotid artery (ICA) and 20 controls were studied by a 2 MHz transcranial Doppler (TCD) at rest and after stimulation with 1 g acetazolamide i.v., a cerebral vasodilator. In addition, the patients underwent 99mTc-HM-PAO-Spect measurement of regional cerebral blood flow (rCBF) at rest and after stimulation with 1 g acetazolamide. In 10 patients with ICA stenoses greater than 80% or occlusions, time-mean velocity (Vmean) increase and pulsatility index (PI) decrease in the postobstructive middle cerebral artery (MCA) as well as the increase of the ipsilateral rCBF were reduced in comparison with the contralateral side. The remaining 5 patients showed a normal Vmean increase and PI decrease in TCD.

摘要

对15例有脑缺血症状且经血管造影证实存在颅外颈内动脉（ICA）单侧狭窄或闭塞的患者以及20名对照者，在静息状态下以及静脉注射1克脑血管扩张剂乙酰唑胺刺激后，用2兆赫兹经颅多普勒（TCD）进行了研究。此外，这些患者在静息状态下以及静脉注射1克乙酰唑胺刺激后，接受了99mTc-HM-PAO单光子发射计算机断层扫描（SPECT）测量局部脑血流量（rCBF）。在10例ICA狭窄大于80%或闭塞的患者中，与对侧相比，阻塞后大脑中动脉（MCA）的时间平均流速（Vmean）增加和搏动指数（PI）降低以及同侧rCBF的增加均减少。其余5例患者在TCD中显示Vmean正常增加和PI正常降低。