[皮肤吗啡在两类脊椎动物代表中的鼻内作用机制]
[The mechanism of the intranasal action of dermorphin in representatives of 2 classes of vertebrates].
作者信息
Chernova L S, Kamenskiĭ A A, Maliukina G A, Baturina E Iu, Deĭgin V I, Iarova E P
出版信息
Zh Evol Biokhim Fiziol. 1992 Jan-Feb;28(1):45-8.
PMID:1355940
Abstract
It has been shown that endogenous opioid dermorphin induces effective analgesia after intranasal injection to fish (0.02-0.20 mg/kg) and rats (0.005 mg/kg). Maintenance of dermorphin analgesia after olfactory and trigeminal denervation indicates that the analgetic effect is not realized via the olfactory receptors or free terminals of the trigeminal nerve.
摘要
研究表明，内源性阿片肽德尔吗啡经鼻注射给鱼（0.02 - 0.20毫克/千克）和大鼠（0.005毫克/千克）后可诱导有效的镇痛作用。嗅觉和三叉神经去神经支配后德尔吗啡镇痛作用的维持表明，镇痛作用不是通过嗅觉受体或三叉神经的游离终末实现的。
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