Fukagawa Y, Funada M, Mizoguchi H, Narita M, Suzuki T, Misawa M
Department of Food and Nutrition, Fukushima Women's College, Japan.
Arukoru Kenkyuto Yakubutsu Ison. 1992 Jun;27(3):266-75.
Effects of dietary proteins such as casein and egg albumin on analgesic activity of, tolerance to and physical dependence on morphine in rats were examined. There was no difference in analgesic activity after acute administration of morphine 10 mg/kg, s.c. between rats treated with casein food or egg albumin food and normal food for 5 or 21 days. The development of tolerance to morphine analgesia in rats treated with albumin food but not with casein food was suppressed during daily morphine 10 mg/kg, s.c. on 5 consecutive days. Rats were treated with casein or albumin food mixed with morphine (0.5 mg/g of food) for 5 days. Morphine intake in rats treated with albumin food was significantly decreased as compared to that with morphine admixed casein or normal food. Body weight loss by naloxone in morphine-dependent rats was significantly less in both casein food and albumin food groups than in the normal food group. These results suggest that chronic dietary treatment with albumin may produce a partial inhibition of development of tolerance to morphine analgesia and that with casein may attenuate morphine withdrawal manifestation in rats.
研究了酪蛋白和卵清蛋白等膳食蛋白质对大鼠吗啡镇痛活性、耐受性及身体依赖性的影响。用酪蛋白食物、卵清蛋白食物或普通食物喂养大鼠5天或21天后，皮下注射10mg/kg吗啡，急性给药后的镇痛活性无差异。在连续5天每天皮下注射10mg/kg吗啡期间，用卵清蛋白食物而非酪蛋白食物喂养的大鼠对吗啡镇痛的耐受性发展受到抑制。大鼠用含吗啡（0.5mg/g食物）酪蛋白或卵清蛋白食物喂养5天。与含吗啡的酪蛋白或普通食物喂养的大鼠相比，用卵清蛋白食物喂养的大鼠吗啡摄入量显著降低。在吗啡依赖大鼠中，酪蛋白食物组和卵清蛋白食物组因纳洛酮导致的体重减轻均显著低于普通食物组。这些结果表明，长期用卵清蛋白膳食处理可能对吗啡镇痛耐受性的发展产生部分抑制作用，而用酪蛋白处理可能减轻大鼠吗啡戒断表现。
