多巴胺对大鼠胃动力的影响。
The effect of dopamine on rat gastric motility.
作者信息
Nagahata Y, Urakawa T, Kuroda H, Tomonaga K, Idei H, Kawakita N, Yoshizumi K, Saitoh Y
机构信息
First Department of Surgery, Kobe University School of Medicine, Japan.
出版信息
Gastroenterol Jpn. 1992 Aug;27(4):482-7. doi: 10.1007/BF02777783.
The inhibitory mechanism of dopamine (DA) on rat gastric motility was investigated in association with DA receptors. Gastric movement was assessed according to the method of Jacoby et al and was expressed with the system of Ludwick et al. (1968). DA inhibited gastric movement in both the corpus and antrum in a dose-dependent manner. Domperidone, a specific antagonist of DA2 receptor, suppressed DA-induced inhibition of gastric movement in a dose-dependent manner. SCH23390, a specific antagonist of DA1 receptor did not affect DA-induced inhibition of gastric movement. LY171555, a specific agonist of DA2 receptor, inhibited gastric movement in both the corpus and antrum in a dose-dependent manner. SKF38393, a specific agonist of DA1 receptor, did not affect gastric movement. These results indicate that DA plays an important role in the inhibitory regulation of gastric motility, through DA2 receptor but not DA1 receptor.
结合多巴胺（DA）受体研究了多巴胺对大鼠胃动力的抑制机制。胃运动按照雅各比等人的方法进行评估，并采用卢德维克等人（1968年）的系统表示。多巴胺以剂量依赖性方式抑制胃体和胃窦的运动。多潘立酮，一种DA2受体的特异性拮抗剂，以剂量依赖性方式抑制多巴胺诱导的胃运动抑制。SCH23390，一种DA1受体的特异性拮抗剂，不影响多巴胺诱导的胃运动抑制。LY171555，一种DA2受体的特异性激动剂，以剂量依赖性方式抑制胃体和胃窦的运动。SKF38393，一种DA1受体的特异性激动剂，不影响胃运动。这些结果表明，多巴胺通过DA2受体而非DA1受体在胃动力的抑制调节中起重要作用。
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