选择性α2 -肾上腺素能受体拮抗剂阿替美唑可增加熊猴雄性的性行为。

Increased sexual behavior in male Macaca arctoides monkeys produced by atipamezole, a selective alpha 2-adrenoceptor antagonist.

作者信息

Linnankoski I, Grönroos M, Carlson S, Pertovaara A

机构信息

Department of Physiology, University of Helsinki, Finland.

出版信息

Pharmacol Biochem Behav. 1992 May;42(1):197-200. doi: 10.1016/0091-3057(92)90467-t.

DOI:10.1016/0091-3057(92)90467-t

PMID:1356274

Abstract

The effect of a highly selective and potent alpha 2-adrenoceptor antagonist, atipamezole, on sexual behavior was studied in three stumptail macaques (Macaca arctoides). Following IM administration of atipamezole or saline control, the behavior of the male monkey with a female monkey was observed for 30 min. Atipamezole dose dependently (0.01-0.15 or 0.30 mg/kg) produced a significant increase in the number of ejaculations in all three monkeys, including an old one with decreased sexual activity in control conditions. Both ejaculations obtained by copulation and masturbation were increased. It is concluded that atipamezole is effective in increasing sexual behavior in male stumptail monkeys.

摘要

在三只短尾猕猴（Macaca arctoides）中研究了一种高选择性强效α2-肾上腺素能受体拮抗剂阿替美唑对性行为的影响。肌肉注射阿替美唑或生理盐水对照后，观察雄性猴子与雌性猴子相处30分钟的行为。阿替美唑剂量依赖性地（0.01 - 0.15或0.30mg/kg）使所有三只猴子的射精次数显著增加，包括一只在对照条件下性活动降低的老年猴子。通过交配和自慰获得的射精次数均增加。得出结论，阿替美唑可有效增加雄性短尾猕猴的性行为。