[胸腺切除对亚致死剂量照射后造血骨髓淋巴样再生的影响]

[Influence of thymectomy on the lymphoid regeneration of hematopoietic bone marrow after sublethal irradiation].

作者信息

Moens P, Boniver J, Haot J, Delrez M, Courtoy R, Simar L J

出版信息

C R Seances Soc Biol Fil. 1976 Oct;170(3):698-702.

Abstract

In C57BL mice, bone marrow lymphoid regeneration after a sublethal irradiation is modified by a graft of normal marrow cells. This effect is suppressed in thymectomized mice since a lymphoid peak is observed after a 350 R irradiation; its composition is heterogeneous: small lymphocytes, lymphoblasts and peculier cells named "X cells". The same phenomenon is observed in mice where all the thymocytes and thymus derived and peripheral lymphocytes are destroyed. These results exclude that bone marrow lymphoid regeneration after irradiation is due to a migration of lymphoid cells of thymic origin to the marrow. They could be explained by the effect of a humoral thymic factor on marrow lymphopoiesis.

摘要

在C57BL小鼠中，亚致死剂量照射后的骨髓淋巴样再生会因正常骨髓细胞移植而改变。在胸腺切除的小鼠中这种效应受到抑制，因为在350拉德照射后可观察到一个淋巴样高峰；其组成是异质性的：小淋巴细胞、淋巴母细胞以及名为“X细胞”的特殊细胞。在所有胸腺细胞以及胸腺来源的和外周淋巴细胞均被破坏的小鼠中也观察到同样的现象。这些结果排除了照射后骨髓淋巴样再生是由于胸腺来源的淋巴样细胞迁移至骨髓所致。它们可以通过胸腺体液因子对骨髓淋巴细胞生成的作用来解释。

相似文献

1

[Influence of thymectomy on the lymphoid regeneration of hematopoietic bone marrow after sublethal irradiation].[胸腺切除对亚致死剂量照射后造血骨髓淋巴样再生的影响]

C R Seances Soc Biol Fil. 1976 Oct;170(3):698-702.

2

The effect of thymectomy on the competitive potential of C57BL/6 bone marrow graft.胸腺切除对C57BL/6骨髓移植竞争潜力的影响。

Exp Hematol. 1976 Jul;4(4):201-8.

3

[Lymphoid regeneration of hematopoietic marrow in mice subjected to whole-body irradiation of 400 R followed by a local irradiation of the thymus].[对接受400伦琴全身照射后再进行胸腺局部照射的小鼠造血骨髓的淋巴细胞再生]

C R Seances Soc Biol Fil. 1970;164(10):2150-2.

4

[Lymphoid regeneration of the hematopoietic bone marrow in thymectomized adult mice irradiated with a sublethal dose].

C R Seances Soc Biol Fil. 1971;165(6):1467-9.

5

[Influence of the thymus gland on lymphoid regeneration in the rat after administration of lethal doses of myleran and a marrow graft].[给予致死剂量马利兰及骨髓移植后胸腺对大鼠淋巴组织再生的影响]

Pathol Biol (Paris). 1969 Apr;17(7):365-9.

6

[Effect of the thymus on the ability of hematopoietic stem cells to recover from sublethal radiation injuries].

Biull Eksp Biol Med. 1978 Nov;86(11):584-6.

7

[Effect of removal of sections of the hematopoietic system on the lymphoid population of the bone marrow in sublethally irradiated mice].

Dokl Akad Nauk SSSR. 1973 Mar 11;209(2):472-4.

8

The role of a thymus humoral factor in the proliferation of bone marrow CFU-S from thymectomized mice.胸腺体液因子在去胸腺小鼠骨髓CFU-S增殖中的作用

Exp Hematol. 1975 Nov;3(6):389-98.

9

Intrathymic T cell differentiation in radiation bone marrow chimeras and its role in T cell emigration to the spleen. An immunohistochemical study.辐射骨髓嵌合体中胸腺内T细胞分化及其在T细胞迁移至脾脏中的作用。一项免疫组织化学研究。

J Immunol. 1985 Jun;134(6):3615-24.

10

[Migration of bone marrow cells to the thymus in mice after a single sublethal-dose irradiation].[单次亚致死剂量照射后小鼠骨髓细胞向胸腺的迁移]

C R Seances Soc Biol Fil. 1982;176(3):384-90.

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