Surolia N, Padmanaban G
Department of Biochemistry, Indian Institute of Science, Bangalore.
Biochem Biophys Res Commun. 1992 Sep 16;187(2):744-50. doi: 10.1016/0006-291x(92)91258-r.
The human malarial parasite, Plasmodium falciparum, has been found to synthesize heme de novo, despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite delta-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability.
已发现人类疟原虫恶性疟原虫能够从头合成血红素，尽管其积累了大量源自红细胞宿主血红蛋白的聚合血红素。疟原虫的δ-氨基乙酰丙酸脱水酶水平显著低于宿主，并且其被琥珀酰丙酮抑制会导致疟原虫蛋白质合成和生存能力受到抑制。
