Kinsella J P, Neish S R, Shaffer E, Abman S H
Department of Pediatrics, Children's Hospital, Denver, Colorado 80218-1088.
Lancet. 1992 Oct 3;340(8823):819-20. doi: 10.1016/0140-6736(92)92687-b.
We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.
我们研究了吸入一氧化氮（NO）对9名患有严重持续性肺动脉高压（PPHN）且适合体外膜肺氧合治疗的新生儿的影响。使用低剂量的NO（10 - 20 ppm）时，所有患儿的氧合情况均迅速改善，且体循环血压未降低。在6名接受吸入NO治疗24小时的婴儿中，6 ppm的剂量可维持临床改善效果。
