Polak M J, Kennedy L A, Drummond W H
Department of Pediatrics, West Virginia University School of Medicine, Morgantown 26506.
Life Sci. 1992;51(17):1317-23. doi: 10.1016/0024-3205(92)90630-8.
Using an isolated, perfused rat lung model, we examined the hypoxic pulmonary vasoconstriction (HPV). We studied the alterations in HPV induced by the selective DA1 receptor agonist, fenoldopam, the selective DA1 antagonist, SCH 23390, as well as a combination of these agents. Fenoldopam significantly attenuated HPV. SCH 23390 had no effect on HPV, but was ableto block the effect of fenoldopam. These data confirm the presence of vasodilatory DA1 receptors in the pulmonary vascular bed. The data further suggest that ongoing DA1 activity may be important in counterbalancing some pathologic pulmonary hypertensive states.
利用离体灌注大鼠肺模型，我们研究了缺氧性肺血管收缩（HPV）。我们研究了选择性DA1受体激动剂非诺多泮、选择性DA1拮抗剂SCH 23390以及这些药物联合使用对HPV的影响。非诺多泮显著减弱了HPV。SCH 23390对HPV无影响，但能够阻断非诺多泮的作用。这些数据证实了肺血管床中存在血管舒张性DA1受体。数据进一步表明，持续的DA1活性可能在对抗某些病理性肺动脉高压状态中起重要作用。
