Freskgård P O, Bergenhem N, Jonsson B H, Svensson M, Carlsson U
Institutionen för Fysik och Mätteknik/Department of Chemistry, Linköping University, Sweden.
Science. 1992 Oct 16;258(5081):466-8. doi: 10.1126/science.1357751.
Several proteins have been discovered that either catalyze slow protein-folding reactions or assist folding in the cell. Prolyl isomerase, which has been shown to accelerate rate-limiting cis-trans peptidyl-proline isomerization steps in the folding pathway, can also participate in the protein-folding process as a chaperone. This function is exerted on an early folding intermediate of carbonic anhydrase, which is thereby prevented from aggregating, whereas the isomerase activity is performed later in the folding process.
