钙离子通道阻滞剂在兔体内由α1和β肾上腺素能受体刺激引起的胰岛素分泌中的作用。
Role of Ca2+ channel blockers in insulin secretion resulting from alpha 1- and beta-adrenoceptor stimulation in the rabbit.
作者信息
García-Barrado M J, Reverte M, Moratinos J
机构信息
Department of Pharmacology, School of Medicine, University of Salamanca, Spain.
出版信息
Eur J Pharmacol. 1992 Sep 4;219(3):461-4. doi: 10.1016/0014-2999(92)90489-q.
In conscious fasted rabbits the i.v. infusion of amidephrine (alpha 1-agonist) or isoprenaline (beta-agonist) induced an increase in plasma levels of immunoreactive insulin. The alpha 1-mediated response was suppressed in animals pretreated with calcium channel blockers (verapamil and elgodipine). The potentiated insulin secretory response in rabbits exposed to dual (alpha 1 + beta) adrenoceptor stimulation was also prevented by verapamil and elgodipine. These results suggest that extracellular calcium is required to mediate the effects of amidephrine on insulin secretion and to support potentiation.
在清醒禁食的家兔中，静脉输注去氧肾上腺素（α1激动剂）或异丙肾上腺素（β激动剂）可导致免疫反应性胰岛素的血浆水平升高。在用钙通道阻滞剂（维拉帕米和依高地平）预处理的动物中，α1介导的反应受到抑制。维拉帕米和依高地平也可阻止家兔在接受双重（α1 + β）肾上腺素能受体刺激时增强的胰岛素分泌反应。这些结果表明，细胞外钙是介导去氧肾上腺素对胰岛素分泌的作用并支持增强作用所必需的。
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