抗糖尿病磺脲类药物在体外可拮抗生长抑素对催乳素分泌的抑制作用。
Antidiabetic sulfonylureas antagonize somatostatin inhibition of prolactin secretion in vitro.
作者信息
Fosset M, Epelbaum J, Lazdunski M
机构信息
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
出版信息
Eur J Pharmacol. 1992 Sep 22;220(2-3):273-4. doi: 10.1016/0014-2999(92)90760-2.
PMID:1358652
Abstract
Somatostatin-induced inhibition of prolactin secretion from adenohypophysis cells in culture is antagonized by the sulfonylurea glipizide, a specific blocker of ATP-sensitive K+ channels. The affinity constant for glipizide is K0.5 = 10 +/- 5 nM.
摘要
生长抑素诱导培养的腺垂体细胞催乳素分泌受抑制，可被磺脲类药物格列吡嗪拮抗，格列吡嗪是ATP敏感性钾通道的特异性阻滞剂。格列吡嗪的亲和常数为K0.5 = 10±5 nM。
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