Yin F C, Ting C T
Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21205.
J Hypertens Suppl. 1992 Aug;10(6):S31-3.
Although arterial compliance has been estimated by a variety of methods none of them can be directly validated because it is difficult to measure arterial volume. Moreover, because arterial pressure-volume relationships are non-linear, compliance is pressure-dependent. We have developed a method of estimating arterial compliance based on the Windkessel model of the arterial system that can account for the pressure-dependence of compliance.
Compared to normotensive humans, compliance was decreased in hypertension and normalized with alpha-blockade, angiotensin converting enzyme inhibition and vasodilators, but not with beta-blockade. Compliance changes with aging, exercise and some diseases were determined.
The decreased compliance seen in hypertension was due to an intrinsic change in the arterial wall, most likely due to increased smooth muscle tone.
尽管已经通过多种方法来估计动脉顺应性，但由于难以测量动脉容积，这些方法均无法得到直接验证。此外，由于动脉压力-容积关系是非线性的，顺应性取决于压力。我们基于动脉系统的Windkessel模型开发了一种估计动脉顺应性的方法，该方法可以解释顺应性的压力依赖性。
与血压正常的人相比，高血压患者的顺应性降低，而α受体阻滞剂、血管紧张素转换酶抑制剂和血管扩张剂可使其恢复正常，但β受体阻滞剂则不能。确定了顺应性随年龄、运动和某些疾病的变化情况。
高血压患者中观察到的顺应性降低是由于动脉壁的内在变化，最可能是由于平滑肌张力增加所致。
