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小白菊(Tanacetum parthenium (L.) Schultz-Bip.)中小白菊内酯的含量及生物活性。市售及经鉴定的小白菊产品的评估。

Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.). Estimation of commercial and authenticated feverfew products.

作者信息

Heptinstall S, Awang D V, Dawson B A, Kindack D, Knight D W, May J

机构信息

Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham, UK.

出版信息

J Pharm Pharmacol. 1992 May;44(5):391-5. doi: 10.1111/j.2042-7158.1992.tb03631.x.

Abstract

Three physicochemical methods (HPLC, NMR spectroscopy, and HPLC of a derivative) have been used to measure parthenolide in authenticated Tanacetum parthenium (feverfew) and in several commercial purported feverfew products. A bioassay based on inhibition of the secretory activity of blood platelets by extracts of feverfew in comparison with parthenolide was also used. Similar results were obtained for all three physicochemical assays and also for the bioassay. Thus different methodologies yield consistent values for parthenolide content of feverfew preparations. Parthenolide appears to be mainly responsible for the antisecretory effects of extracts of feverfew. Authenticated Tanacetum parthenium grown in the UK contained a high level of parthenolide in leaves, flowering tops and seeds but a low level in stalks and roots. The level of parthenolide in powdered leaf material fell during storage. The purported feverfew products varied widely in their parthenolide content and in some products parthenolide was not detected. Possible reasons for the variation in parthenolide content are discussed. Since therapeutic efficacy has only been demonstrated for preparations of feverfew that contain parthenolide, it is suggested that manufacturers of feverfew products should use measurements of parthenolide as a means of standardization and quality control.

摘要

三种物理化学方法(高效液相色谱法、核磁共振光谱法以及衍生物的高效液相色谱法)已被用于测定经鉴定的小白菊(西洋蓍草)以及几种声称是小白菊的商业产品中的小白菊内酯。还采用了一种生物测定法,该方法基于将小白菊提取物与小白菊内酯相比较,对血小板分泌活性的抑制作用。所有三种物理化学测定法以及生物测定法都得到了相似的结果。因此,不同的方法得出的小白菊制剂中小白菊内酯含量的值是一致的。小白菊内酯似乎是小白菊提取物抗分泌作用的主要原因。在英国种植的经鉴定的小白菊,其叶片、花顶部和种子中含有高水平的小白菊内酯,但茎和根中的含量较低。粉状叶片材料中的小白菊内酯含量在储存过程中下降。声称是小白菊的产品,其小白菊内酯含量差异很大,在一些产品中未检测到小白菊内酯。文中讨论了小白菊内酯含量变化的可能原因。由于仅对含有小白菊内酯的小白菊制剂证明了其治疗效果,因此建议小白菊产品制造商应将小白菊内酯的测量作为标准化和质量控制的一种手段。

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