Smith S
Department of Obstetrics and Gynecology, Sinai Hospital of Baltimore, Maryland 21215.
J Reprod Med. 1992 Aug;37(8):737-40.
Six stable psychiatric outpatients with hyperprolactinemia and amenorrhea/oligomenorrhea associated with their neuroleptic medications were treated with bromocriptine. Daily dosages of 5-10 mg corrected the hyperprolactinemia and restored menstruation in four of the six patients. One woman, however, developed worsened psychiatric symptoms while taking bromocriptine, and it was discontinued. Thus, three of six patients had their menstrual irregularity successfully corrected with bromocriptine. This suggests that bromocriptine should be further evaluated as potential therapy for neuroleptic-associated hyperprolactinemia and amenorrhea/galactorrhea.
六名患有高催乳素血症以及与抗精神病药物相关的闭经/月经过少的稳定期精神科门诊患者接受了溴隐亭治疗。每日5 - 10毫克的剂量使六名患者中的四名患者的高催乳素血症得到纠正且月经恢复。然而，有一名女性在服用溴隐亭时出现了更严重的精神症状，于是停用了该药。因此，六名患者中有三名患者的月经不调通过溴隐亭成功得到纠正。这表明溴隐亭应作为抗精神病药物相关高催乳素血症和闭经/溢乳的潜在治疗方法进行进一步评估。
