两性霉素与喷他脒治疗锑剂无反应性黑热病的对比

Amphotericin versus pentamidine in antimony-unresponsive kala-azar.

作者信息

Mishra M, Biswas U K, Jha D N, Khan A B

机构信息

Department of Medicine, Darbhanga Medical College & Hospital, Bihar, India.

出版信息

Lancet. 1992 Nov 21;340(8830):1256-7. doi: 10.1016/0140-6736(92)92952-c.

DOI:10.1016/0140-6736(92)92952-c

PMID:1359322

Abstract

We compared the efficacy of amphotericin B and pentamidine isethionate in a prospective randomised trial in 120 uncomplicated and parasitologically confirmed cases of antimony-unresponsive kala-azar. Doses were twenty intramuscular injections of pentamidine 4 mg/kg on alternate days or fourteen definitive doses of amphotericin 0.5 mg/kg infused in 5% dextrose on alternate days. 48 (80%) patients given pentamidine showed initial cure and 46 (77%) showed definitive cure compared with 60 (100%) and 59 (98%) cases, respectively, on amphotericin (p < 0.001). Amphotericin also brought about quicker abatement of fever and more complete spleen regression.

摘要

在一项前瞻性随机试验中，我们比较了两性霉素B和喷他脒异硫氰酸盐对120例未经复杂治疗且经寄生虫学确诊的锑无反应型黑热病病例的疗效。剂量为每两天肌肉注射20次，每次喷他脒4mg/kg，或每两天在5%葡萄糖中静脉输注14次，每次两性霉素0.5mg/kg。接受喷他脒治疗的48例（80%）患者初步治愈，46例（77%）最终治愈，而接受两性霉素治疗的患者分别为60例（100%）和59例（98%）（p<0.001）。两性霉素还能更快地退热，脾脏回缩更完全。