Wojańska B
II Kliniki Psychiatrycznej Katedry Psychiatrii AM, Lodzi.
Pol Tyg Lek. 1992;47(9-10):238-40.
Gilles de la Tourette syndrome is a condition marked by: (1) onset usually in childhood and adolescence, i.e. between 2 and 15 years of life; (2) violent facial tics and echolalia; (3) increased excitability and apathy; (4) progressive increase in symptoms intensity; (5) chronic course. This syndrome is threefold more frequent in men than in women. None hypothesis concerning its etiopathogenesis (genetic, organic, organic-functional, psychomotor, and mixed) does explain its origin. Many cases respond with some degree of relief to neuroleptics, carbamazepine, clonidine, and glucocorticosteroids. Neurosurgery and psychotherapy are also of value. Haloperidol is commonly considered the most effective in this syndrome.
(1)通常在儿童期和青少年期发病,即2至15岁之间;(2)剧烈的面部抽搐和模仿言语;(3)兴奋性增加和冷漠;(4)症状强度逐渐增加;(5)病程慢性化。该综合征在男性中的发病率是女性的三倍。关于其病因发病机制(遗传、器质性、有机功能性、精神运动性和混合性)的任何假设都无法解释其起源。许多病例对抗精神病药、卡马西平、可乐定和糖皮质激素有一定程度的缓解反应。神经外科手术和心理治疗也有价值。氟哌啶醇通常被认为是治疗该综合征最有效的药物。