Githeko A K, Brandling-Bennett A D, Beier M, Atieli F, Owaga M, Collins F H
Kenya Medical Research Institute, Vector Biology and Control Research Centre, Kisumu.
Trans R Soc Trop Med Hyg. 1992 Jul-Aug;86(4):355-8. doi: 10.1016/0035-9203(92)90216-y.
The reservoir of infectious Plasmodium falciparum gametocytes in a population living in an area of holoendemic malaria in western Kenya was estimated by directly feeding mosquitoes on volunteers. Resulting mosquito infections were assessed both by midgut examination for oocysts and by enzyme-linked immunosorbent assay for P. falciparum circumsporozoite antigen. Calculations based on the age structure of the population and the resulting rates of mosquito infections indicated that children under 10 years of age were responsible for 72% of mosquito infections, individuals between 10 and 21 years of age contributed 12%, and those over 21 years of age accounted for 16%. No infection resulted in mosquitoes fed on infants less than 1 year of age.
通过让蚊子直接叮咬肯尼亚西部疟疾高度流行地区的志愿者，估算了该地区人群中感染性恶性疟原虫配子体的储存宿主。通过对中肠进行卵囊检查以及采用酶联免疫吸附测定法检测恶性疟原虫环子孢子抗原，对产生的蚊子感染情况进行了评估。根据人群年龄结构和由此得出的蚊子感染率进行计算表明，10岁以下儿童导致了72%的蚊子感染，10至21岁个体占12%，21岁以上个体占16%。以小于1岁的婴儿为叮咬对象的蚊子未出现感染情况。
