Gloeb D J, Lai S, Efantis J, O'Sullivan M J
Department of Obstetrics and Gynecology, University of Miami School of Medicine/Jackson Memorial Medical Center, Florida.
Am J Obstet Gynecol. 1992 Jul;167(1):152-7. doi: 10.1016/s0002-9378(11)91650-0.
Our objective was to provide information on survival and disease progression in human immunodeficiency virus antibody-positive pregnant women undergoing prospective evaluation.
After an index delivery, 103 human immunodeficiency virus antibody-positive pregnant women were identified and underwent follow-up for 3 years. The patients were assessed medically and/or gynecologically when hospitalized for a human immunodeficiency virus-related illness or at each follow-up visit. The life-table method was used to estimate the cumulative probabilities of survival and remaining free of acquired immunodeficiency syndrome. Cox's proportional-hazards analyses were used to identify prognostic factors for survival and progression to acquired immunodeficiency syndrome.
The majority of human immunodeficiency virus-infected pregnant women were alive 3 years later. Lymphadenopathy syndrome or herpes genitalis was significantly associated with a subsequent diagnosis of acquired immunodeficiency syndrome. Of the 103 original patients, six had acquired immunodeficiency syndrome at the index delivery and acquired immunodeficiency syndrome developed in 24. Approximately 94% of evaluable patients with development of acquired immunodeficiency syndrome had CD4-lymphocyte counts < 200/mm3. The most common opportunistic infection was Pneumocystis carinii pneumonia. Acquired immunodeficiency syndrome and postpartum zidovudine therapy were independent prognostic factors affecting survival.
Survival was affected by Centers for Disease Control group status of human immunodeficiency virus infection at the index delivery.
我们的目的是提供关于接受前瞻性评估的人类免疫缺陷病毒抗体阳性孕妇的生存情况和疾病进展的信息。
在一次索引分娩后，确定了103名人类免疫缺陷病毒抗体阳性孕妇，并对其进行了3年的随访。当因与人类免疫缺陷病毒相关的疾病住院或每次随访时，对患者进行医学和/或妇科评估。采用寿命表法估计生存和未患获得性免疫缺陷综合征的累积概率。使用Cox比例风险分析来确定生存和进展为获得性免疫缺陷综合征的预后因素。
大多数感染人类免疫缺陷病毒的孕妇在3年后仍然存活。淋巴结病综合征或生殖器疱疹与随后诊断为获得性免疫缺陷综合征显著相关。在最初的103名患者中，6名在索引分娩时患有获得性免疫缺陷综合征，24名患者发展为获得性免疫缺陷综合征。在发展为获得性免疫缺陷综合征的可评估患者中，约94%的患者CD4淋巴细胞计数<200/mm3。最常见的机会性感染是卡氏肺孢子虫肺炎。获得性免疫缺陷综合征和产后齐多夫定治疗是影响生存的独立预后因素。
生存受索引分娩时人类免疫缺陷病毒感染的疾病控制中心组状态影响。
