Capocchi G, Zampolini M, Larson J
Istituto di Clinica delle Malattie Nervose e Mentali, University of Perugia, Italy.
Brain Res. 1992 Sep 25;591(2):332-6. doi: 10.1016/0006-8993(92)91715-q.
The efficacy of stimulation patterns consisting of brief high frequency bursts repeated at various intervals to induce long-term potentiation (LTP) at synapses on apical and basal dendrites of CA1 hippocampal neurons was tested in vitro. Both apical and basal dendritic synapses exhibited maximal LTP after bursts repeated at 5-10 Hz, i.e. close to the frequency of the endogenous hippocampal theta rhythm. As at apical dendritic synapses, LTP at basal dendritic synapses was blocked by an antagonist of NMDA receptors. Basal dendritic LTP was significantly greater in magnitude than apical dendritic LTP, although the reason for this is unknown.
在体外测试了由以不同间隔重复的短暂高频爆发组成的刺激模式在CA1海马神经元顶树突和基底树突突触处诱导长时程增强（LTP）的功效。顶树突和基底树突突触在以5-10Hz重复爆发后均表现出最大的LTP，即接近内源性海马θ节律的频率。与顶树突突触一样，基底树突突触处的LTP被NMDA受体拮抗剂阻断。基底树突LTP的幅度明显大于顶树突LTP，尽管其原因尚不清楚。
