Murray A M, Ryoo H, Joyce J N
Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.
Eur J Pharmacol. 1992 Dec 1;227(4):443-5. doi: 10.1016/0922-4106(92)90164-q.
In sections of human brain containing the striatum (caudate, nucleus, putamen, nucleus accumbens) the competition for binding of [125I]epidepride by compounds with differing selectivity for dopamine D2 and D3 receptors was examined. Domperidone showed higher affinity for D2-like than D3-like sites whereas 7-OH-DPAT (7-hydroxy-2-(N,N-di-n-propylamino)tetralin) and quinpirole demonstrated the reverse selectivity. The pattern of [125I]epidepride binding in the presence of a high concentration of domperidone was negligible in the dorsal striatum but indicated islands of dense binding to D3-like receptors in the nucleus accumbens and ventral putamen.
在包含纹状体（尾状核、壳核、伏隔核）的人脑切片中，研究了对多巴胺D2和D3受体具有不同选择性的化合物对[125I]表哌立登结合的竞争情况。多潘立酮对D2样位点的亲和力高于D3样位点，而7-OH-DPAT（7-羟基-2-（N，N-二正丙基氨基）四氢萘）和喹吡罗则表现出相反的选择性。在高浓度多潘立酮存在的情况下，[125I]表哌立登在背侧纹状体中的结合模式可忽略不计，但显示在伏隔核和腹侧壳核中有密集结合D3样受体的区域。
