催乳素生物测定与高催乳素血症
Prolactin bioassay and hyperprolactinemia.
作者信息
Peabody C A, Schultz P N, Warner M D, Worsley I G, Friesen H G, Samaan N A
机构信息
Department of Psychiatry, University of Texas Medical School, Houston.
出版信息
J Endocrinol Invest. 1992 Jul-Aug;15(7):497-9. doi: 10.1007/BF03348787.
The Nb2 rat lymphoma bioassay (BA) for prolactin (PRL) was performed in 26 subjects with hyperprolactinemia, 17 of whom had radiologic evidence of a pituitary adenoma. All subjects were treated with the long acting dopamine agonist CV 205-502. The radioimmunoassay (RIA) PRL significantly decreased with treatment but the BA/RIA PRL remained essentially the same, indicating that the relative bioactivity was unaffected.
对26名高催乳素血症患者进行了用于催乳素（PRL）的Nb2大鼠淋巴瘤生物测定（BA），其中17人有垂体腺瘤的放射学证据。所有受试者均接受长效多巴胺激动剂CV 205 - 502治疗。放射免疫测定（RIA）的PRL水平在治疗后显著下降，但BA/RIA的PRL基本保持不变，表明相对生物活性未受影响。
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