镉抑制鳐（Raja erinacea）电器官中的刺激-反应偶联。

Cadmium inhibits stimulus-response coupling in skate (Raja erinacea) electric organ.

Brown O M, Andrake J S

Department of Pharmacology, State University of New York Health Science Center, Syracuse 13210.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Jul;102(3):439-46. doi: 10.1016/0742-8413(92)90139-x.

Abstract

The effects of cadmium on stimulus-response coupling in the skate (Raja erinacea) electric organ were examined. 2. Cadmium decreased the evoked electrical discharge and the evoked release of 3H-ACh in a concentration-related fashion. 3. Cadmium (100 microM) also blocked voltage-dependent 45Ca uptake. 4. Both d-tubocurarine and nifedipine blocked Ca uptake and evoked potential, but not 3H-ACh release, thus most of the 45Ca uptake measured was post-synaptic through L Ca channels. 5. Nickel, cadmium, and verapamil inhibited 3H-ACh release and evoked potential, indicating a block of pre-synaptic T Ca channels.

摘要

研究了镉对鳐（Raja erinacea）电器官中刺激-反应偶联的影响。2. 镉以浓度相关的方式降低了诱发的放电和3H-ACh的诱发释放。3. 镉（100微摩尔）也阻断了电压依赖性45Ca摄取。4. d-筒箭毒碱和硝苯地平都阻断了Ca摄取和诱发电位，但不阻断3H-ACh释放，因此所测量的大部分45Ca摄取是通过L型Ca通道在突触后进行的。5. 镍、镉和维拉帕米抑制了3H-ACh释放和诱发电位，表明阻断了突触前T型Ca通道。