通过移植亲代骨髓细胞在F1杂种中获得造血重建。
Hemopoietic reconstitution obtained in F1 hybrids by grafting of parental marrow cells.
作者信息
von Boehmer H, Sprent J, Nabholz M
出版信息
Transplant Proc. 1976 Sep;8(3):355-8.
T-cell tolerance to CML and MLR determinants in tetraparental bone marrow chimeras, prepared by injecting lethally x-irradiated F1 hybrids with bone marrow cells from both parental strains, is most likely due to clonal deletion. Tolerance to CML, but not to the host's MLR, determinants is observed when lethally x-irradiated F1 hybrids are repopulated with bone marrow from one parental strain only. The results demonstrate that removal of T cells from donor cells, as well as exclusion of a HVG reaction, make it possible to transplant bone marrow between allogeneic individuals.
通过向经致死剂量X射线照射的F1杂种注射来自两个亲本品系的骨髓细胞制备的四亲代骨髓嵌合体中，T细胞对慢性髓细胞白血病（CML）和混合淋巴细胞反应（MLR）决定簇的耐受性很可能是由于克隆清除。当仅用来自一个亲本品系的骨髓对经致死剂量X射线照射的F1杂种进行再填充时，可观察到对CML决定簇的耐受性，但对宿主的MLR决定簇则没有耐受性。结果表明，从供体细胞中去除T细胞以及排除宿主抗移植物反应（HVG反应），使得在同种异体个体之间进行骨髓移植成为可能。
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