四亲代骨髓嵌合体对组织相容性决定簇的耐受性
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras.
作者信息
Boehmer H, Sprent J, Nabholz M
出版信息
J Exp Med. 1975 Feb 1;141(2):322-34. doi: 10.1084/jem.141.2.322.
Abstract
Tetraparental bone marrow chimeras were produced by injecting lethally X-irradiated F1 hybrids with relatively high numbers of T-cell-depleted bone marrow cells from both allogeneic parental strains. The mice survival in excellent health and showed a stable, approximately 50:50 (parent:parent), lymphoid cell chimerism lasting for at least 7 mo after irradiation; regeneration of host-type hemopoietic cells was very limited. Thymus, lymph node, and thoracic duct lymphocytes showed specific unresponsiveness to host mixed leukocyte reaction (MLR) determinants. Similarly specific tolerance to H-2 antigens of host type was demonstrated in spleen and lymph node. No suppressor cells could be demonstrated in either system and blocking serum factors could not be found. The results suggest specific deletion of functional T cells reactive to host-type MLR and cell-mediated lympholysis determinants.
摘要
通过给经致死剂量X射线照射的F1杂种小鼠注射来自两个同种异体亲本品系的大量去除T细胞的骨髓细胞，制备了四亲代骨髓嵌合体。这些小鼠健康状况良好，存活下来，并表现出稳定的、大约50:50（亲本:亲本）的淋巴细胞嵌合状态，在照射后至少持续7个月；宿主型造血细胞的再生非常有限。胸腺、淋巴结和胸导管淋巴细胞对宿主混合淋巴细胞反应（MLR）决定簇表现出特异性无反应性。在脾脏和淋巴结中也证明了对宿主型H-2抗原的类似特异性耐受性。在这两个系统中均未发现抑制细胞，也未发现阻断血清因子。结果表明，对宿主型MLR和细胞介导的淋巴细胞溶解决定簇有反应的功能性T细胞发生了特异性缺失。
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本文引用的文献
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Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats.新生大鼠皮肤同种异体移植耐受性诱导及矮小病的定量研究。
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Tolerance and homologous disease in irradiated mice protected with homologous bone marrow.用同源骨髓保护的受辐照小鼠的耐受性和同源疾病。
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"Intrinsic" immunological tolerance in allophenic mice.异表型小鼠中的“内在”免疫耐受性。
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Quantitative studies on the mixed lymphocyte interaction in rats. II. Relationship of the proliferative response to the immunologic status of the donors.大鼠混合淋巴细胞相互作用的定量研究。II. 增殖反应与供体免疫状态的关系。
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Immunological tolerance: "forbidden clones" allowed in tetraparental mice.免疫耐受：四亲代小鼠中允许存在“禁忌克隆”。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1644-7. doi: 10.1073/pnas.68.7.1644.
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Cell-to-cell interaction in the immune response. VI. Contribution of thymus-derived cells and antibody-forming cell precursors to immunological memory.免疫反应中的细胞间相互作用。VI. 胸腺衍生细胞和抗体形成细胞前体对免疫记忆的作用。
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Lymphocytes and transplantation immunity.淋巴细胞与移植免疫。
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