左旋千金藤啶碱对大鼠纹状体酪氨酸羟化酶活性的影响。
Effects of l-stepholidine on tyrosine hydroxylase activity in rat corpus striatum.
作者信息
Guo X, Chen L J, Buda M, Jin G Z
机构信息
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
出版信息
Zhongguo Yao Li Xue Bao. 1992 Jul;13(4):289-92.
l-Stepholidine (SPD) 2.5 and haloperidol (Hal) 1.0 mg.kg-1 ip increased rat striatal L-3,4-dihydroxyphenylalanine (DOPA) and 3,4-dihydroxyphenylacetic acid (DOPAC) accumulation induced by NSD 1015 (50 mg.kg-1, ip), a decarboxylase inhibitor. SPD (2.5 mg.kg-1, ip) did not alter but apomorphine (2.0 mg.kg-1, ip) decreased the dopamine (DA) content elevated by gamma-butyrolactone (GBL, 750 mg.kg-1, ip) in the rat striatum. Ip injection of either SPD 5.0 or Hal 2.5 mg.kg-1 after NSD 1015 50 mg.kg-1 or NSD 1015 plus GBL 750 mg.kg-1 also augmented tyrosine hydroxylase (TH) activity in the rat striatum. These results suggest that SPD produces an antagonistic effect on presynaptic DA receptors.
左旋千金藤啶碱（SPD）2.5毫克及氟哌啶醇（Hal）1.0毫克·千克⁻¹腹腔注射可增加由脱羧酶抑制剂NSD 1015（50毫克·千克⁻¹，腹腔注射）诱导的大鼠纹状体L-3,4-二羟基苯丙氨酸（DOPA）和3,4-二羟基苯乙酸（DOPAC）的蓄积。SPD（2.5毫克·千克⁻¹，腹腔注射）未改变，但阿扑吗啡（2.0毫克·千克⁻¹，腹腔注射）降低了由γ-丁内酯（GBL，750毫克·千克⁻¹，腹腔注射）升高的大鼠纹状体多巴胺（DA）含量。在NSD 1015 50毫克·千克⁻¹或NSD 1015加GBL 750毫克·千克⁻¹后腹腔注射SPD 5.0毫克或Hal 2.5毫克·千克⁻¹也增强了大鼠纹状体酪氨酸羟化酶（TH）的活性。这些结果表明SPD对突触前DA受体产生拮抗作用。
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