Haragsim L, Zima T
Institute of Toxicology, Charles University School of Medicine, Prague, Czechoslovakia.
Biochem Int. 1992 Oct;28(2):273-6.
The aim of the study was to compare the nephrotoxic effects of cis-platinum (CDDP) and carboplatinum (CBDCA) and the protective potential of verapamil in rats. CDDP (3 mg/kg) and CBDCA (60 mg/kg) were administered intraperitoneally in a single dose on day 1. Verapamil (0.1 mg/kg) was administered 30 min before i.p. injection. Rats were assayed daily for urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), alkaline phosphatase (AP) and gamma-glutamyl-transferase (GMT), on day 3 they were assayed for creatinine clearance. CBDCA appears to be less nephrotoxic than CDDP. Verapamil shows protective effects against the nephrotoxicity of platinum derivatives in both groups of rats.
本研究的目的是比较顺铂（CDDP）和卡铂（CBDCA）对大鼠的肾毒性作用以及维拉帕米的保护潜力。于第1天腹腔内单剂量注射CDDP（3 mg/kg）和CBDCA（60 mg/kg）。在腹腔注射前30分钟给予维拉帕米（0.1 mg/kg）。每天检测大鼠尿中N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、碱性磷酸酶（AP）和γ-谷氨酰转移酶（GMT）的排泄量，在第3天检测肌酐清除率。CBDCA的肾毒性似乎比CDDP小。维拉帕米对两组大鼠铂类衍生物的肾毒性均有保护作用。
