Protective effects of verapamil on cis-platinum and carboplatinum nephrotoxicity in dehydrated and normohydrated rats.

The aim of the study was to compare the nephrotoxic effects of cis-platinum (CDDP) and carboplatinum (CBDCA) and the protective potential of verapamil in rats. CDDP (3 mg/kg) and CBDCA (60 mg/kg) were administered intraperitoneally in a single dose on day 1. Verapamil (0.1 mg/kg) was administered 30 min before i.p. injection. Rats were assayed daily for urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), alkaline phosphatase (AP) and gamma-glutamyl-transferase (GMT), on day 3 they were assayed for creatinine clearance. CBDCA appears to be less nephrotoxic than CDDP. Verapamil shows protective effects against the nephrotoxicity of platinum derivatives in both groups of rats.