子宫内膜腺癌患者的种族差异。

Racial differences in patients with adenocarcinoma of the endometrium.

作者信息

Cronjé H S, Fourie S, Doman M J, Helms J B, Nel J T, Goedhals L

机构信息

Gynecologic Oncology Group, University of the Orange Free State, Bloemfontein, South Africa.

出版信息

Int J Gynaecol Obstet. 1992 Nov;39(3):213-8. doi: 10.1016/0020-7292(92)90659-7.

DOI:10.1016/0020-7292(92)90659-7

PMID:1360916

Abstract

OBJECTIVE

To determine the differences between white and black women with regard to the presentation and behavior of adenocarcinoma of the endometrium.

METHOD

Records of 273 (68%) white patients and 117 (32%) black patients with endometrial adenocarcinoma were reviewed in Bloemfontein, South Africa. Survival data was calculated according to the direct method where losses in follow-up were regarded as tumor deaths.

RESULTS

Most patients (82%) were treated by pre-operative radium followed by total abdominal hysterectomy and bilateral salpingo-oophorectomy, with post-operative external irradiation where indicated. Pre-operatively, fewer black women had reached FIGO stage I, while a larger number had advanced to stages II-IV (P = 0.0024). In addition, the tumor differentiation was more often poor in the black group (P < 0.0001). Ten-year follow-up was achieved in 84% of the white patients and 51% of the black patients and the 10-year survival figures were 67% for white patients and 28% for blacks (P < 0.0001).

CONCLUSION

Endometrial adenocarcinoma is a more aggressive disease in black women than it is in whites.

摘要

目的

确定白人女性和黑人女性在子宫内膜腺癌的表现及行为方面的差异。

方法

对南非布隆方丹的273例（68%）白人子宫内膜腺癌患者和117例（32%）黑人子宫内膜腺癌患者的记录进行了回顾。生存数据根据直接法计算，随访中的失访被视为肿瘤死亡。

结果

大多数患者（82%）接受术前镭疗，随后进行全腹子宫切除术和双侧输卵管卵巢切除术，并在必要时进行术后外照射。术前，达到国际妇产科联盟（FIGO）I期的黑人女性较少，而进展到II-IV期的黑人女性较多（P = 0.0024）。此外，黑人组肿瘤分化较差的情况更为常见（P < 0.0001）。84%的白人患者和51%的黑人患者获得了10年随访，白人患者的10年生存率为67%，黑人患者为28%（P < 0.0001）。