Numano F
Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Heart Vessels Suppl. 1992;7:68-72. doi: 10.1007/BF01744547.
Takayasu arteritis is a chronic vasculitis characterized by a clinical pulseless condition and is predominant in young female patients. Its loci is found mainly in Asian countries, and its etiology is still unknown. Our experiences of cases of twin sisters with Takayasu arteritis led us to suppose that hereditary factors participate in the pathophysiology of this disease. Population and family-incidence studies employing HLA analysis in Japan have focused on an complotype Aw24-DW52-C4A2-C4BQ0-Dw12 which was in disequilibrium with Takayasu arteritis. Clinical features and clinical courses were found to be intimately related to this complotype. Recent studies on HLA typing in other countries have also suggested the important roles of hereditary factors in this morbid condition and international collaborative studies on these hereditary factors are now under way.
高安动脉炎是一种以临床无脉症为特征的慢性血管炎，主要见于年轻女性患者。其发病区域主要在亚洲国家，病因尚不清楚。我们对患有高安动脉炎的双胞胎姐妹病例的经验使我们推测遗传因素参与了该疾病的病理生理过程。日本采用HLA分析的人群和家族发病率研究集中在一种与高安动脉炎呈不平衡状态的单倍型Aw24 - DW52 - C4A2 - C4BQ0 - Dw12上。发现临床特征和临床病程与这种单倍型密切相关。其他国家最近关于HLA分型的研究也表明遗传因素在这种疾病状态中起重要作用，目前正在进行关于这些遗传因素的国际合作研究。
