Jesch F, Endrich B, Messmer K
Adv Exp Med Biol. 1976;75:105-12. doi: 10.1007/978-1-4684-3273-2_14.
The intravascular persistence of hb-W is significantly longer than of pyridoxylated hb (hb-PLP), however, no significant differences in BV were observed after isovolemic exchange of 20 ml/kg b.w. Even though the oxygen affinity of hb-PLP in vitro was reduced when compared to the affinity of hb-W significant differences in vivo were lacking. The development of hypovolemia and thus the lack of an adequate increase in cardiac output have been recognized as the most relevant causes to explain the changes observed. Neither of the solutions is yet to be recommended for clinical blood replacement therapy.
血红蛋白-W（hb-W）在血管内的存留时间明显长于吡哆醛化血红蛋白（hb-PLP），然而，在以20毫升/千克体重进行等容血液交换后，未观察到血容量（BV）有显著差异。尽管与hb-W相比，hb-PLP在体外的氧亲和力降低，但在体内却没有显著差异。低血容量的发展以及因此缺乏心输出量的充分增加已被认为是解释所观察到变化的最相关原因。这两种溶液都尚未被推荐用于临床血液置换治疗。
