冠状动脉内局部给予亚甲蓝可阻止缺血预处理明显的抗心律失常作用。
The local intracoronary administration of methylene blue prevents the pronounced antiarrhythmic effect of ischaemic preconditioning.
作者信息
Vegh A, Papp J G, Szekeres L, Parratt J
机构信息
Department of Pharmacology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
出版信息
Br J Pharmacol. 1992 Dec;107(4):910-1. doi: 10.1111/j.1476-5381.1992.tb13384.x.
Abstract
Short periods of coronary artery occlusion (2 x 5 min) markedly reduce the severity of arrhythmias and the changes in ST-segment elevation and in the degree of inhomogeneity of conduction during a subsequent 25 min occlusion of the left anterior descending coronary artery in anaesthetized dogs. These changes were completely reversed if methylene blue (5 mg min-1) was infused into a side branch of the coronary artery throughout both the preconditioning and prolonged occlusions. These results suggest that the pronounced antiarrhythmic effects of preconditioning result from activation of guanylyl cyclase and result in increased levels of guanosine 3':5'-cyclic monophosphate.
摘要
在麻醉犬中，短时间冠状动脉闭塞（2×5分钟）可显著减轻随后左前降支冠状动脉25分钟闭塞期间心律失常的严重程度、ST段抬高的变化以及传导不均一性的程度。如果在预处理和延长闭塞期间均将亚甲蓝（5毫克/分钟）注入冠状动脉侧支，则这些变化可完全逆转。这些结果表明，预处理显著的抗心律失常作用源于鸟苷酸环化酶的激活，并导致3':5'-环磷酸鸟苷水平升高。
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