Gerber H, Peter H J, Studer H
Department of Internal Medicine, University of Berne, Inselspital, Switzerland.
Exp Clin Endocrinol. 1992;100(1-2):45-7. doi: 10.1055/s-0029-1211174.
Administration of sera from patients with active Graves' disease to nude mice bearing human thyroid xenografts provides the opportunity to compare directly the effects of TSAb on thyroid tissue of different species. The results presented in this paper, namely the fact that only one of 8 Graves' sera increased the RAIU of the nu/nu mouse thyroids modestly while all sera increased the RAIU in the transplanted human tissue considerable, clearly show a species specific effect of TSAb.
将患有活动性格雷夫斯病患者的血清注射到携带人甲状腺异种移植物的裸鼠体内，为直接比较促甲状腺素受体抗体（TSAb）对不同物种甲状腺组织的作用提供了机会。本文呈现的结果，即8份格雷夫斯病血清中只有1份适度增加了裸鼠甲状腺的放射性碘摄取率（RAIU），而所有血清均显著增加了移植人甲状腺组织的RAIU，清楚地显示了TSAb的物种特异性效应。
