MITOMA C, SMITH T E, DACOSTA F M, UDENFRIEND S, PATCHETT A A, WITKOP B
Science. 1959 Jan 9;129(3341):95-6. doi: 10.1126/science.129.3341.95.
The administration of ketoproline to chick embryos resulted in an increase in the free hydroxyproline. This phenomenon is explained by the inhibitory action of ketoproline on the catabolism of hydroxyproline as well as by the conversion of the former to the latter. Ketoproline was found to be reduced to hydroxyproline by the supernatant fraction of rat-kidney homogenate in the presence of a reduced pyridine nucleotide.
向鸡胚施用酮脯氨酸会导致游离羟脯氨酸增加。这种现象可通过酮脯氨酸对羟脯氨酸分解代谢的抑制作用以及前者向后者的转化来解释。发现在存在还原型吡啶核苷酸的情况下，大鼠肾脏匀浆的上清液部分可将酮脯氨酸还原为羟脯氨酸。
