Sorribas V, Arruebo M P, Navarro H, Alcalde A I
Departamento de Fisiología y Farmacología, Facultad de Veterinaria, Universidad de Zaragoza, España.
J Pharm Pharmacol. 1992 Dec;44(12):1030-2.
Nicarbazin is an anticoccidial drug, used mainly in birds, which has shown several other effects including inhibition of growth and feed efficiency in poultry, and stimulation of sugar and amino acid intestinal absorption in rabbit. The present work was designed to determine whether nicarbazin added to the feed, affects growth and feed intake in rabbit, and whether the continuous ingestion of nicarbazin can alter the mechanisms of intestinal nutrient absorption or digestion in this species. Nicarbazin, administered at the recommended dose (125 ppm) had no harmful effects either on growth or on feed intake of animals. After treatment for one month with nicarbazin at the dose of 125 ppm added to the feed, rabbits displayed a higher transport ability of both D-glucose and L-leucine through the enterocyte plasma membranes than did untreated rabbits. These animals also showed higher specific activities of two brush-border enzymes, sucrase and aminopeptidase N, than the control animals.
尼卡巴嗪是一种抗球虫药，主要用于禽类，它还显示出其他几种作用，包括抑制家禽生长和饲料效率，以及刺激兔子肠道对糖和氨基酸的吸收。本研究旨在确定饲料中添加尼卡巴嗪是否会影响兔子的生长和采食量，以及持续摄入尼卡巴嗪是否会改变该物种肠道营养吸收或消化的机制。以推荐剂量（125 ppm）给药的尼卡巴嗪对动物的生长或采食量均无有害影响。在饲料中添加125 ppm剂量的尼卡巴嗪处理一个月后，兔子对D-葡萄糖和L-亮氨酸通过肠上皮细胞质膜的转运能力高于未处理的兔子。这些动物的两种刷状缘酶——蔗糖酶和氨肽酶N的比活性也高于对照动物。
