Tallerico-Melnyk T, Yip C C, Watt V M
Department of Physiology, University of Toronto, Ontario, Canada.
Biochem Biophys Res Commun. 1992 Dec 15;189(2):610-6. doi: 10.1016/0006-291x(92)92244-r.
Natriuretic peptides modulate vasorelaxation, diuresis, and natriuresis through the stimulation of cGMP production by the guanylate cyclase-coupled natriuretic peptide receptors, GC-A and GC-B. We used reverse transcription-polymerase chain reaction to determine the distribution of mRNA encoding both receptors in rat tissues. GC-A and GC-B transcripts were detected in all peripheral and neural tissues examined. Since the atrial natriuretic peptide gene is expressed in all these tissues, our widespread detection of GC-A and GC-B mRNAs now suggests that natriuretic peptides may act as endocrine and paracrine hormones as well as neurotransmitters via both GC-A and GC-B receptors.
利钠肽通过鸟苷酸环化酶偶联的利钠肽受体GC-A和GC-B刺激环磷酸鸟苷（cGMP）生成，从而调节血管舒张、利尿和利钠作用。我们采用逆转录聚合酶链反应来确定大鼠组织中编码这两种受体的mRNA的分布。在所检测的所有外周组织和神经组织中均检测到了GC-A和GC-B转录本。由于心房利钠肽基因在所有这些组织中均有表达，我们现在广泛检测到的GC-A和GC-B mRNA表明，利钠肽可能通过GC-A和GC-B受体作为内分泌和旁分泌激素以及神经递质发挥作用。
