Teixidó J, Borrás M, Bonet J, Galimany R, Biosca C, Caralps A
Servicio de Nefrologia, Hospital Germans Trias i Pujol, Barcelona, Spain.
Adv Perit Dial. 1992;8:177-80.
The Peritoneal Equilibration Test (PET) as standardized by Twardowski (T) and simplified Mass Transfer Coefficients (MTC) as per Garred (G) and Krediet (K) have been employed in our patients to assess: 1) the reproducibility of results, 2) correlation between methods, and 3) usefulness of patient categorization by simplified methods in contrast to PET patterns. We have performed 29 standardized PET (Dianeal 2.5%) in 24 stable CAPD patients. We have collected dialysate samples at 0, 30, 60, 120, 180 and 240 minutes. With this data we were able to calculate the dialysate/plasma ratio for PET, MTC as per Garred and MTC as per Krediet. Our results were not significantly different from data reported by the original authors, except for PET D/P urea at 240': 0.91 +/- 0.07(T) vs. 0.87 +/- 0.08 (our), p < 0.05. In our patients, good correlation was found between PET and MTC for urea, creatinine, and glucose, using both formulae (G and K). Patient categorization as High, High Average, Low Average, and Low by MTCs can well predict PET categorization with acceptable sensitivity and good specificity. We conclude there is good reproducibility of the methods. There is also a close correlation between PET, K and G methods for solute transport evaluation and patient categorization. Simplified methods can be substituted for the more complex ones.
我们对患者采用了由特瓦尔道斯基（T）标准化的腹膜平衡试验（PET）以及根据加雷德（G）和克雷迪特（K）简化的传质系数（MTC），以评估：1）结果的可重复性；2）方法之间的相关性；3）与PET模式相比，简化方法对患者分类的实用性。我们对24例稳定的持续性非卧床腹膜透析（CAPD）患者进行了29次标准化PET（百特2.5%）。我们在0、30、60、120、180和240分钟时收集了透析液样本。利用这些数据，我们能够计算PET的透析液/血浆比率、加雷德法的MTC和克雷迪特法的MTC。除了240分钟时PET的D/P尿素：0.91±0.07（T）与0.87±0.08（我们的数据），p<0.05外，我们的结果与原作者报告的数据没有显著差异。在我们的患者中，使用两种公式（G和K），发现PET与尿素、肌酐和葡萄糖的MTC之间存在良好的相关性。通过MTC将患者分类为高、高平均、低平均和低，可以很好地预测PET分类，具有可接受的敏感性和良好的特异性。我们得出结论，这些方法具有良好的可重复性。在溶质转运评估和患者分类方面，PET、K和G方法之间也存在密切相关性。简化方法可以替代更复杂的方法。
