Pasadakis P, Thodis E, Euthimiadou A, Panagoutsos S, Oustoglou E, Kartali S, Vargemezis V
Democritus University of Thrace, Division of Nephrology, General District Hospital, Alexdroupolis, Greece.
Adv Perit Dial. 1992;8:238-41.
A total of 16 episodes of peritonitis in 14 patients (9 males, 5 females), were treated with Clavulanate potentiated ticarcillin (TC), a -lactamase stable parenteral penicillin. All the pts were hospitalized and received initial loading dose of 3.2 gr intraperitoneally (i.p.) in a 6-hour 1 L exchange, which was followed by four 1 L exchanges with 320 mg/LTC. The therapy was continued for ten days. The bacteria isolated were: Staph. epid. (4), Staph. aureus (2), Strept. viridans (1), Enterococcus (1), Klebsiella Pneum. (1), Serratia (1), Enterobacter (1), Pseudomonas species: stutszeri (2), cepacia (1), fluorescens (1), negative cultures (1). Recurrence of peritonitis was seen in three patients with Pseudomonas (stutszeri (2), fluorescens (1)) peritonitis, 10-16 days after cessation of therapy. No clinical or biological side effects were seen in any patient during and/or after the therapy. These results suggest that, i.p. monotherapy of TC is effective in the treatment of CAPD peritonitis, while in cases of Pseudomonas peritonitis more specific regimens should be used.
14例患者（9例男性，5例女性）共发生16次腹膜炎，采用克拉维酸增强替卡西林（TC）治疗，TC是一种对β-内酰胺酶稳定的胃肠外青霉素。所有患者均住院治疗，在6小时1L的换液过程中，首次腹腔内给予3.2g负荷剂量，随后进行4次1L换液，每次换液含320mg/L的TC。治疗持续10天。分离出的细菌有：表皮葡萄球菌（4例）、金黄色葡萄球菌（2例）、草绿色链球菌（1例）、肠球菌（1例）、肺炎克雷伯菌（1例）、沙雷菌（1例）、阴沟肠杆菌（1例）、假单胞菌属：施氏假单胞菌（2例）、洋葱伯克霍尔德菌（1例）、荧光假单胞菌（1例）、培养阴性（1例）。3例假单胞菌（施氏假单胞菌（2例）、荧光假单胞菌（1例））性腹膜炎患者在治疗停止后10 - 16天出现腹膜炎复发。治疗期间和/或治疗后，所有患者均未出现临床或生物学副作用。这些结果表明，腹腔内使用TC单一疗法治疗连续性非卧床腹膜透析相关性腹膜炎是有效的，而对于假单胞菌性腹膜炎病例，应采用更具针对性的治疗方案。
