Han D C, Cha H K, So I N, Chung S H, Park M S, Lee S K, Woo J H, Hwang S D, Moon C, Lee H B
Hyonam Kidney Laboratory, Soon Chun Hyang University, Seoul, Korea.
Adv Perit Dial. 1992;8:298-301.
Recent experiences with Y-connectors suggest that the flush-before-fill effectively reduces intraluminal infection. Periluminal infection, however, remains an important route of peritonitis (P). We have recently reported reduced P incidence with the introduction of a new access technique as described by Moncrief in which the external segment of peritoneal catheter is left implanted subcutaneously for 6 weeks before exteriorization and bag exchanges. P developed once every 14.0 patient-mos with the new access while the incidence was one episode per 10.7 mos with conventional access. Significantly fewer patients with the new access compared to those with conventional access experienced P during the observation period (p < 0.01). Although the overall incidence of exit-site infection (ESI) was not different, there were significantly fewer episodes of simultaneous P and ESI with the new access (2P in 47 episodes of ESI) than with conventional access (36P in 126 ESI). While 10 of the 36 episodes of simultaneous infection in the conventional technique were caused by same organisms, none of the 2 episodes with the new access technique was caused by same organisms.
The results of this study suggest that the new access technique reduces P incidence by virtually eliminating infection by the periluminal route.
近期使用Y形连接器的经验表明,先冲洗再填充可有效减少腔内感染。然而,管周感染仍是腹膜炎(P)的重要途径。我们最近报告称,采用Moncrief描述的一种新的置管技术后,P的发生率有所降低,该技术是将腹膜导管的外部段在皮下植入6周后再外置并更换袋子。采用新置管技术时,每14.0患者-月发生1次P,而传统置管技术的发生率为每10.7月1次。在观察期内,采用新置管技术的患者发生P的人数明显少于采用传统置管技术的患者(p < 0.01)。虽然出口部位感染(ESI)的总体发生率没有差异,但采用新置管技术时同时发生P和ESI的情况(47次ESI中有2次P)明显少于传统置管技术(126次ESI中有36次P)。在传统技术的36次同时感染中,有10次是由相同微生物引起的,而采用新置管技术的2次感染中,没有一次是由相同微生物引起的。
本研究结果表明,新的置管技术通过几乎消除管周途径感染来降低P的发生率。