猫组织和体液中甲基戊炔醇及甲基戊炔醇氨基甲酸酯的分布。
The distribution of methylpentynol and of methylpentynol carbamate in tissues and body fluids of cats.
作者信息
MARLEY E, VANE J R
出版信息
Br J Pharmacol Chemother. 1958 Dec;13(4):364-71. doi: 10.1111/j.1476-5381.1958.tb00222.x.
A method is described for the estimation of methylpentynol and methylpentynol carbamate in body fluids and tissues. After intravenous administration, the distribution of these drugs throughout the body was found to be similar to that of ethanol. They entered cells, and crossed the blood-brain barrier and the placenta. They were excreted or secreted into the saliva, milk, gastric secretion, aqueous and vitreous humour, amniotic liquor, bile and urine. Methylpentynol was found in the expired air. Calculation of the volume of distribution and measurement of concentration in the tissues showed that both drugs were only slowly metabolized or excreted, suggesting the possibility that blood concentrations might rise cumulatively over a period of days.
本文描述了一种用于估算体液和组织中甲基戊炔醇及甲基戊炔醇氨基甲酸酯的方法。静脉给药后，发现这些药物在体内的分布与乙醇相似。它们进入细胞，穿过血脑屏障和胎盘。它们被排泄或分泌到唾液、乳汁、胃液、房水和玻璃体、羊水、胆汁及尿液中。在呼出的气体中发现了甲基戊炔醇。分布容积的计算和组织中浓度的测量表明，这两种药物的代谢或排泄都很缓慢，这表明血药浓度可能在数天内累积升高。
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