氨基甲酸甲基戊炔醇及其代谢物3-甲基戊炔-3,4-二醇的气相色谱分析

Gas-liquid chromatography of methylpentynol carbamate and its metabolite 3-methylpentyne-3,4-diol.

作者信息

Grove J, Martin B K

出版信息

J Chromatogr. 1977 Mar 21;133(2):267-72. doi: 10.1016/s0021-9673(00)83483-4.

Abstract

Procedures are described for the determination of methylpentynol carbamate in serum, either by injection into the chromatograph of diluted serum or extraction of the drug into chloroform and injection of an aliquot of the concentrated organic phase; a 4% CDMS column is used. Similar assays for measuring the metabolite 3-methylpentyne-3,4-diol in urine are reported. The methods have been used for measuring methylpentynol carbamate and its metabolite in samples from rats and dogs.

摘要

介绍了测定血清中甲戊炔醇氨基甲酸酯的方法，可将稀释后的血清注入色谱仪，或将药物萃取到氯仿中，再取浓缩有机相的一份等分试样注入色谱仪；使用的是4% CDMS柱。还报道了类似的用于测定尿液中代谢物3-甲基戊炔-3,4-二醇的分析方法。这些方法已用于测定大鼠和狗样本中甲戊炔醇氨基甲酸酯及其代谢物。