基底核大细胞部损伤大鼠的海马长时程增强效应

Hippocampal long-term potentiation in nucleus basalis magnocellularis-lesioned rats.

作者信息

Frank C, Sagratella S, Niglio T, Caporali M G, Bronzetti E, Scotti de Carolis A

机构信息

Laboratorio di Farmacologia, Istituto Superiore di Sanità, Roma, Italy.

出版信息

Brain Res Bull. 1992 Dec;29(6):847-51. doi: 10.1016/0361-9230(92)90154-p.

DOI:10.1016/0361-9230(92)90154-p

PMID:1361876

Abstract

The probability of hippocampal long-term potentiation induction in the mossy fiber CA3 and commissural/associational CA3 responses and the cortical levels of choline acetyltransferase (ChAT) activity were compared in right nucleus basalis magnocellularis (NBM)-lesioned rats. A 50% reduction in the right cortical ChAT activity was demonstrated 4 weeks after an ibotenic acid lesion of the NBM. No significative differences were found in the probability of LTP induction of right hippocampal slices in sham-operated rats from 10 to 40 days after the injection into the right NBM. On the contrary, a progressive and significative increase in the probability of LTP induction was shown in right hippocampal slices of NBM-lesioned rats from 10 to 40 days after the injection of ibotenic acid into the right NBM. The results demonstrated the appearance of a paradoxical increase of hippocampal synaptic plasticity when the cortical cholinergic biochemical alterations are still present. This finding might be responsible for a behavioural recovery, in NBM-lesioned rats.

摘要

在右侧基底核大细胞部（NBM）损伤的大鼠中，比较了苔藓纤维CA3和联合/联络CA3反应中海马长时程增强诱导的概率以及胆碱乙酰转移酶（ChAT）活性的皮质水平。在NBM经鹅膏蕈氨酸损伤4周后，右侧皮质ChAT活性降低了50%。在向右侧NBM注射后10至40天，假手术大鼠右侧海马切片LTP诱导概率未发现显著差异。相反，在向右侧NBM注射鹅膏蕈氨酸后10至40天，NBM损伤大鼠右侧海马切片LTP诱导概率呈渐进性显著增加。结果表明，当皮质胆碱能生化改变仍然存在时，海马突触可塑性出现了矛盾性增加。这一发现可能是NBM损伤大鼠行为恢复的原因。