钙通道阻滞剂与小脑切片中钾刺激的谷氨酸释放
Calcium channel blocking agents and potassium-stimulated release of glutamate from cerebellar slices.
作者信息
Dickie B G, Davies J A
机构信息
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Heath Park, Cardiff, UK.
出版信息
Eur J Pharmacol. 1992 Dec 8;229(1):97-9. doi: 10.1016/0014-2999(92)90291-b.
The effects of calcium channel blockers and tetrodotoxin on the potassium-stimulated release of endogenous glutamate from rat cerebellar slices was assessed. Verapamil (10 microM), omega-conotoxin (1 and 10 microM) and cobalt (2 mM) all significantly decreased release. Amiloride (100 microM) and tetrodotoxin (0.5 and 1 microM) had no effect. The results suggest a role for N-type voltage-operated calcium channels in the potassium-stimulated release of glutamate.
评估了钙通道阻滞剂和河豚毒素对大鼠小脑切片中钾刺激的内源性谷氨酸释放的影响。维拉帕米（10微摩尔）、ω-芋螺毒素（1和10微摩尔）和钴（2毫摩尔）均显著降低了释放量。氨氯吡咪（100微摩尔）和河豚毒素（0.5和1微摩尔）没有影响。结果表明N型电压门控钙通道在钾刺激的谷氨酸释放中起作用。
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