人胰岛素瘤中胰岛素原和胰岛素的分布模式：76例肿瘤的免疫组织化学分析

Distribution patterns of proinsulin and insulin in human insulinomas: an immunohistochemical analysis in 76 tumors.

作者信息

Roth J, Klöppel G, Madsen O D, Storch M J, Heitz P U

机构信息

Department of Pathology, University of Zürich, Switzerland.

出版信息

Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;63(1):51-61. doi: 10.1007/BF02899244.

DOI:10.1007/BF02899244

PMID:1362022

Abstract

The distribution of proinsulin and insulin immunoreactivity was studied in 76 human insulinomas and in normal pancreas. One trabecular and two solid insulinomas showed the staining pattern of normal beta cells. A "near normal" staining pattern (perinuclear proinsulin and diffuse or polarized insulin staining) existed in 10 of 27 trabecular and 11 of 44 solid insulinomas. An "intermediate" staining pattern (intense perinuclear as well as weaker diffuse proinsulin staining with diffuse or polarized insulin staining) was observed in 10 of 27 trabecular and 20 of 44 solid insulinomas. Different "abnormal" staining patterns were found in 6 of 27 trabecular and 6 of 44 solid insulinomas. Of the 5 glandular insulinomas, 4 exhibited a "near normal" and one an "abnormal" staining pattern. No correlation was found between any particular staining pattern and the multihormonality or malignancy of the insulinomas. The diffuse labeling for proinsulin in about 50% of the insulinomas is suggestive of abnormal prohormone processing.

摘要

对76例人胰岛素瘤和正常胰腺中胰岛素原和胰岛素免疫反应性的分布进行了研究。1例小梁状和2例实性胰岛素瘤呈现正常β细胞的染色模式。27例小梁状胰岛素瘤中的10例和44例实性胰岛素瘤中的11例存在“近正常”染色模式（核周胰岛素原和弥漫性或极化性胰岛素染色）。在27例小梁状胰岛素瘤中的10例和44例实性胰岛素瘤中的20例观察到“中间”染色模式（强烈的核周以及较弱的弥漫性胰岛素原染色伴弥漫性或极化性胰岛素染色）。在27例小梁状胰岛素瘤中的6例和44例实性胰岛素瘤中的6例发现了不同的“异常”染色模式。5例腺性胰岛素瘤中，4例呈现“近正常”染色模式，1例呈现“异常”染色模式。未发现任何特定染色模式与胰岛素瘤的多激素分泌或恶性程度之间存在相关性。约50%的胰岛素瘤中胰岛素原的弥漫性标记提示激素原加工异常。