Just M, Berger R
Childrens Hospital, University of Basle, Switzerland.
Vaccine. 1992;10 Suppl 1:S110-3. doi: 10.1016/0264-410x(92)90560-7.
Two inactivated hepatitis A virus (HAV) candidate vaccine strain were tested, derived from strains CLF and HM175. Neither vaccine increased liver enzymes levels and reactogenicity was similar to that observed with other alum-absorbed products. Antibody responses were dose-dependent and protection against HAV can be presumed to last for at least three years. All persons receiving 720 ELISA units (El.U) of the CLF vaccine seroconverted after one dose. For the HM175 vaccine, anti-HAV persisted until month 12 after injections at months 0 and 1, suggesting that the third dose of vaccine could be given at any time from month 6 to 12. A double dose of HM175 vaccine (1440 El.U) given as a single bolus resulted in 100% seroconversion by day 14 with a geometric mean anti-HAV level of 121 mIU/ml. This implies that rapid protection can be induced using large doses of inactivated HAV vaccine should time constraints dictate such an approach.
对两种源自CLF株和HM175株的甲型肝炎病毒（HAV）灭活候选疫苗株进行了测试。两种疫苗均未提高肝酶水平，其反应原性与其他铝吸附产品观察到的相似。抗体反应呈剂量依赖性，可推测对HAV的保护作用至少持续三年。所有接受720酶联免疫吸附测定单位（El.U）CLF疫苗的人在一剂后均发生血清转化。对于HM175疫苗，在第0个月和第1个月注射后，抗-HAV持续至第12个月，这表明第三剂疫苗可在第6个月至第12个月的任何时间接种。单次推注给予双倍剂量的HM175疫苗（1440 El.U），到第14天时血清转化率达100%，几何平均抗-HAV水平为121 mIU/ml。这意味着如果时间紧迫，使用大剂量的灭活HAV疫苗可诱导快速保护。
