高静水压对脊椎动物神经中可卡因和藜芦碱作用的影响。
The influence of high hydrostatic pressure on cocaine and veratrine action in a vertebrate nerve.
作者信息
GERSHFELD N L, SHANES A M
出版信息
J Gen Physiol. 1959 Jan 20;42(3):647-53. doi: 10.1085/jgp.42.3.647.
Abstract
The application of high hydrostatic pressure to toad sciatic nerve causes a gain in sodium and a loss of potassium which are not affected by cocaine. However, cocaine action is enhanced by high pressure when counteracting veratrine depolarization and when blocking the action potential. Various effects of elevated pressure on the after-potentials are presented and the role of ions in these processes is discussed.
摘要
对蟾蜍坐骨神经施加高静水压会导致钠的增加和钾的流失，这不受可卡因的影响。然而，在对抗藜芦碱去极化和阻断动作电位时，可卡因的作用会因高压而增强。本文介绍了压力升高对后电位的各种影响，并讨论了离子在这些过程中的作用。
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本文引用的文献
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Ionic transfer in nerve in relation to bio-electrical phenomena.神经中的离子转移与生物电现象的关系。
Ann N Y Acad Sci. 1952 Jun 30;55(1):1-36. doi: 10.1111/j.1749-6632.1952.tb26518.x.
2
The ultraviolet spectra and neurophysiological effects of "veratrine" alkaloids.“藜芦碱”生物碱的紫外光谱及神经生理效应
J Pharmacol Exp Ther. 1952 Jun;105(2):216-31.
3
Factors in nerve functioning.神经功能的影响因素。
Fed Proc. 1951 Sep;10(3):611-21.
4
Response of single nerve fibers at different hydrostatic pressures.不同静水压力下单根神经纤维的反应。
Am J Physiol. 1957 Apr;189(1):214-8. doi: 10.1152/ajplegacy.1957.189.1.214.
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