精神分裂症与多巴胺D3受体基因纯合性之间的关联。
Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
作者信息
Crocq M A, Mant R, Asherson P, Williams J, Hode Y, Mayerova A, Collier D, Lannfelt L, Sokoloff P, Schwartz J C
机构信息
Centre Hospitalier, Rouffach, France.
出版信息
J Med Genet. 1992 Dec;29(12):858-60. doi: 10.1136/jmg.29.12.858.
Abstract
Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).
摘要
多巴胺神经传递紊乱被认为是精神分裂症的潜在病因。我们报告了两项关于精神分裂症患者多巴胺D3受体基因中一个BalI多态性的独立研究数据。在两项研究中，纯合子的患者均多于对照组（p = 0.005，p = 0.008）。对汇总数据进行分析时，这种差异具有高度显著性（p = 0.0001），纯合子患精神分裂症的相对风险为2.61（95%置信区间1.60 - 4.26）。
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