Shaikh S, Ball D, Craddock N, Castle D, Hunt N, Mant R, Owen M, Collier D, Gill M
Genetics Section, Institute of Psychiatry, De Crespigny Park, London.
J Med Genet. 1993 Apr;30(4):308-9. doi: 10.1136/jmg.30.4.308.
Bipolar affective disorder and schizophrenia share many clinical and genetic characteristics, and are thought by some to be different expressions of the same underlying disorder. A recent study showed an excess of homozygosity at a BalI polymorphism in the dopamine D3 receptor gene in schizophrenic patients compared with controls, from two independent centres. We have found no evidence of such an excess in a comparable sample of patients with bipolar affective disorder compared with matched controls. If these findings are confirmed then at least one genetic distinction between these two disorders will have been ascertained and doubt cast upon theories of a common genetic aetiology.
双相情感障碍和精神分裂症有许多临床和遗传特征，一些人认为它们是同一潜在疾病的不同表现形式。最近一项研究表明，与对照组相比，来自两个独立中心的精神分裂症患者在多巴胺D3受体基因的BalI多态性处纯合性过高。我们发现在双相情感障碍患者的可比样本中，与匹配的对照组相比，没有这种过高的证据。如果这些发现得到证实，那么这两种疾病之间至少有一个遗传差异将被确定，同时关于共同遗传病因的理论也会受到质疑。
