Weller M, Kornhuber J
National Institutes of Health, Clinical Neuroscience Branch, Bethesda, MD 20892.
Br J Psychiatry. 1992 Dec;161:855-6. doi: 10.1192/bjp.161.6.855.
Nine out of 4044 patients admitted to our institution between 1987 and 1990 suffered an episode of NMS. Neuroleptic rechallenge using clozapine for persisting psychiatric illness was tolerated by eight patients. Clozapine was discontinued in one older, high-risk patient because recurrence of NMS was anticipated. Clozapine should be considered a drug of choice for psychotic patients with a history of NMS.
1987年至1990年间，我院收治的4044例患者中有9例发生了恶性综合征（NMS）。8例持续性精神疾病患者使用氯氮平进行抗精神病药物再激发试验，结果耐受良好。1例老年高危患者因预计会复发NMS而停用氯氮平。对于有NMS病史的精神病患者，氯氮平应被视为首选药物。
