Dallegri F, Ottonello L
Department of Internal Medicine, University of Genova Medical School, Italy.
Arch Immunol Ther Exp (Warsz). 1992;40(1):39-42.
When activated by a variety of stimuli, human neutrophils become capable of lysing tumour cells. The main physiologic cytotoxic trigger in neutrophils is represented by the surface receptor for the Fc domain of IgG (FcR). This receptor confers specificity to the target recognition by neutrophils and cooperates with adhesion glycoproteins (CD11-CD18) in the neutrophil-target conjugate formation. Although the FcR-dependent pathways of signal transduction remain to be clarified, the neutrophil responses involve both the production of oxidants and the release of granule constituents. These molecules are responsible for the target lysis, whose extent also depends on the target structural and metabolic characteristics. The use of monoclonal antibodies specific for tumour cell antigens, coupled with appropriate cytokines, may provide rational basis for designing trials to employ the neutrophil cytotoxic potential as adjuvant therapy in cancer patients.
在受到多种刺激激活后，人类中性粒细胞能够裂解肿瘤细胞。中性粒细胞主要的生理性细胞毒性触发因素是免疫球蛋白G（IgG）Fc结构域的表面受体（FcR）。该受体赋予中性粒细胞对靶标的识别特异性，并在中性粒细胞与靶标的结合形成过程中与黏附糖蛋白（CD11 - CD18）协同作用。尽管FcR依赖的信号转导途径仍有待阐明，但中性粒细胞的反应涉及氧化剂的产生和颗粒成分的释放。这些分子负责靶标的裂解，其程度还取决于靶标的结构和代谢特征。使用针对肿瘤细胞抗原的单克隆抗体，并结合适当的细胞因子，可能为设计利用中性粒细胞细胞毒性潜力作为癌症患者辅助治疗的试验提供合理依据。
